What are the names of two endogenous cannabinoids?

Endogenous cannabinoids, also known as endocannabinoids, are naturally occurring compounds in the body that bind to cannabinoid receptors and play key roles in various physiological processes. The correct answer highlights AEA (anandamide) and 2-AG (2-arachidonoylglycerol) as the two primary endocannabinoids.

AEA is synthesized from the membrane lipid precursors and is well-known for its role in modulating pain, mood, appetite, and memory. It shares structural similarities with THC, a psychoactive compound found in cannabis, but AEA does not come from the plant.

On the other hand, 2-AG is another important endocannabinoid that plays a significant role in neuroprotection, immune response, and modulating neurotransmitter release. Both AEA and 2-AG are synthesized in a post-synaptic manner and released in response to neuronal activity, affecting the presynaptic neuron when they bind to cannabinoid receptors.

The other options mentioned either include cannabinoids derived from the cannabis plant (like THC and CBD) or are not classified as cannabinoids at all (such as GABA and glutamate, which are neurotransmitters). Therefore, the recognition of AEA and 2-AG as endogenous cannabinoids