What is a unique feature of methamphetamine's action compared to cocaine?

Methamphetamine's unique feature is its ability to promote the release of neurotransmitters, particularly dopamine, in a way that is more pronounced than that of cocaine. While both substances are stimulants and affect the dopaminergic system, their mechanisms of action differ significantly.

Cocaine primarily acts as a reuptake inhibitor, blocking the serotonin, norepinephrine, and dopamine transporters. This prevents the reabsorption of these neurotransmitters back into the presynaptic neuron, thereby increasing their levels in the synaptic cleft. However, it does not actively promote their release.

In contrast, methamphetamine has a dual action: it not only inhibits the reuptake of dopamine, but it also causes the release of dopamine from the presynaptic neuron into the synaptic space. This leads to a much stronger and prolonged activation of the dopaminergic system, resulting in greater psychoactive effects and potential for addiction compared to cocaine.

The other options do not accurately reflect distinctive characteristics associated with methamphetamine’s action compared to cocaine. The inhibition of sodium channels is more relevant to local anesthetics, stimulation of the parasympathetic nervous system is not a characteristic effect of either substance, and destruction of dopamine receptors is not an inherent action of