What substance is formed when cocaine is mixed with alcohol?

When cocaine is mixed with alcohol, the substance formed is called cocaethylene. This compound arises through the process of transesterification, where ethanol from alcohol interacts with cocaine, resulting in cocaethylene, which exhibits both stimulant properties due to the cocaine structure and some additional effects through the ethanol component.

Cocaethylene can have significant clinical implications, particularly in the context of substance use. It is known to have a longer half-life than cocaine alone, contributing to more prolonged effects and potential for increased toxicity, including cardiovascular complications. Understanding the formation of cocaethylene is important for addiction medicine practitioners, as it highlights the risks associated with the concurrent use of cocaine and alcohol and emphasizes the importance of patient education regarding the dangers of mixing these substances.

By knowing that cocaethylene is formed when cocaine and alcohol are combined, healthcare professionals can better assess risks, manage potential complications, and provide appropriate interventions for patients presenting with substance use disorders involving these substances.