Which medication has shown efficacy for cannabis use disorder in adults?

The medication that has shown efficacy for cannabis use disorder in adults is N-acetylcysteine. This compound is an antioxidant with potential Neuromodulatory effects, and clinical studies have indicated that it may reduce cravings and withdrawal symptoms associated with cannabis use.

N-acetylcysteine works by modulating glutamate levels in the brain and may help restore healthy brain function that can be disrupted by chronic cannabis use. As a result, it has gained attention in addiction treatment contexts, particularly for cannabis use disorder, where patients may experience cravings and difficulty reducing or stopping their use.

While other medications like gabapentin, fluoxetine, and clonidine have been explored in various contexts of addiction or mental health, they are not specifically supported by research for treating cannabis use disorder in adults. Gabapentin primarily addresses neuropathic pain and anxiety, fluoxetine is an antidepressant, and clonidine can help with withdrawal symptoms but lacks substantial evidence directly targeting cannabis use disorder.